WZ3146 Size:10mg solid InChi: InChI=1S/C18H15FN4O3S/c1-12-9-14(13-7-8-20-21-11-13)10-16(17(12)19)18(24)22-23-27(25

InChi: InChI=1S/C18H15FN4O3S/c1-12-9-14(13-7-8-20-21-11-13)10-16(17(12)19)18(24)22-23-27(25

1401532-80-6 (SAG(cis）)

40 μM) inhibits pancreatic cancer cell invasion and cell growth

PF-06447475 is well tolerated in rats

In contrast to type II inhibitors of CDK8 and CDK19

WZ3146 Size:10mg solid InChi: InChI=1S/C18H15FN4O3S/c1-12-9-14(13-7-8-20-21-11-13)10-16(17(12)19)18(24)22-23-27(25WZ 3146 is a covalent or irreversible pyrimidine based EGFR inhibitor against EGFR T790M. WZ 3146 was identified by screening an irreversible kinase inhibitor library specifically against EGFR T790M. WZ 3146 potently suppresses the growth of EGFR T790M containing cell lines and inhibits EGFR phosphorylation. WZ 3146 is also effective in murine models of lung cancer driven by EGFR T790M. WZ 3146 may be clinically more effective and better tolerated